Posted on 31 Jan, 2023

Lower back pain is very common and it affects individuals of all ages. According to the 2015 Global Burden of Disease StudyTrusted Source, 7.3% of the global population — or 540 million people — experience activity-limiting lower back pain at any one time, and this symptom is the leading cause of disability worldwide.

Certain lifestyle factors are associated with a higher riskTrusted Source of lower back pain. These include physically demanding jobs, smoking, obesity, and low levels of physical activity.

However, in most cases, it is not possible to pinpoint the specific cause of lower back pain. In a small percentage of cases, lower back pain can be attributed to cancer, a vertebral fracture, an infection, or an inflammatory disorder.

Lower back pain and sleep

Several studies have shown that poor sleep quality and lower back pain are correlated.

A cross-sectional studyTrusted Source conducted among 9,611 participants concluded that lower back pain is associated with short sleep duration and poor sleep quality.

In another studyTrusted Source, researchers assessed sleep quality and pain intensity in 80 patients with lower back pain. They observed that a night of poor sleep quality was followed by a day with higher pain intensity.

Furthermore, a day with higher pain intensity was associated with a decrease in the subsequent night’s sleep quality, suggesting a bidirectional relationship between sleep quality and pain intensity in patients with lower back pain.

Although previous research has shown that poor sleep quality is common in patients with lower back pain, the causal relationship between sleep quality and lower back pain remains unclear.

Now, researchers at Zhejiang University School of Medicine conducted a study to investigate the causal relationship between sleep disturbances and lower back pain. Their findings appear in Frontiers in Neuroscience.

Studying the role of sleep disturbances

A genome-wide association studyTrusted Source (GWAS) involves scanning the genetic material of a large number of people to identify genes associated with particular traits.

Dr. Ge Luo and his colleagues obtained self-reported data and genetic information from a GWAS including 336,965 individuals of European ancestry. The data for the GWAS came from the UK Biobank — a database containing genetic and health data from half a million individuals across the UK.

To assess the causal relationship between sleep disturbances and lower back pain, the researchers selected individuals from the GWAS cohort who had genetic variants associated with the following types of sleep disturbances:

insomnia
short sleep duration
long sleep duration
daytime sleepiness.

The researchers then used a type of statistical analysis known as Mendelian randomizationTrusted Source analysis to estimate the causal effect between different sleep disturbances and lower back pain.

Based on the results of these statistical analyses, the researchers concluded that there is a bidirectional causal relationship between insomnia and lower back pain, which means that insomnia can cause lower back pain, and vice versa.

They also found that a genetic predisposition to short or long sleep duration did not increase the risk of lower back pain.

Finally, the researchers found that a genetic predisposition to lower back pain could increase the risk of daytime sleepiness, but they found no reverse causal relationship.

Study implications

To date, lower back pain is primarily treated using analgesics. If the hypothesis that insomnia causes lower back pain is true, then sleep regulators may potentially be used to manage lower back pain.

Dr. Jie Sun, a pain physician at Peking University who has explored the bidirectional relationships between sleep disorders and pain, not involved in the current study, told MNT that certainty regarding the effectiveness of existing interventions for lower back pain is low to moderate, and novel treatments are “desperately required” for patients living with both sleep disturbances and lower back pain.

Dr. Sun expressed optimism that “[u]nderstanding the underlying mechanisms of how sleep disturbance interplays with chronic pain is likely to lead to better-directed treatment.”

“Dr. Luo’s research implied a possible causal relationship [between] insomnia [and] low back pain, which is consistent with the [m]eta-analysis of longitudinal studies’ findings that a decline in sleep quality and quantity was associated with a two- or three-fold increase in the risk of developing pain condition,” Dr. Sun told us.

Study limitations and next steps

In the paper, the researchers acknowledged that their study had a few limitations. First, the participants included in this study were of European ancestry, thus, the results may not be equally applicable to other ethnic groups.

Then, the possible effect of pleiotropy — when one gene influences two or more traits — on the results cannot be completely excluded, they noted. Moreover, the authors admitted that the study did not take into consideration all possible types of sleep disturbances.

Finally, since gender influences the risk for lower back pain, it may be better to calculate the estimations within the subgroup based on gender stratification, they cautioned.

When contacted by MNT to comment on the study, Prof. Christopher G. Maher, professor at the Sydney School of Public Health, University of Sydney, not involved in this research, expressed some skepticism, and pointed out several shortcomings of the study paper, including that “[t]he authors do not even specify how they measured low back pain.”

In Dr. Sun’s opinion, “the [large number] of genetic cases and strictness of the statistical analysis make the conclusion stringent.”

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